Shear Wave Speed and Attenuation as Surrogate Imaging Biomarkers for the Quantification of Liver Fibrosis and Inflammation
Ahmed M. Gharib 1 , Simon Lambert 2 , Khaled Z. Abd-Elmoniem 1 , Ahmed A. Harouni 1 , Theo Heller 1 , Caryn Morse 1 , and Ralph Sinkus 3
National Institutes of Health, Bethesda, MD,
of Imaging Sciences and Biomedical Engineering, Kings
College, London, England, United Kingdom,
of Imaging Sciences and Biomedical Engineering, King's
College, London, England, United Kingdom
Liver MR-elastography (MRE) was performed at 3T on 17
patients with known biopsy proven chronic liver disease.
Shear wave speed and the shear wave attenuation were
calculated at 26Hz and 58Hz. Both frequencies
demonstrated increase shear wave speed that closely
follows an increase in fibrosis. However, at 56Hz the
shear wave attenuation strongly increases for
fibrosis:inflammation ratio <1. This indicates a
potential clinical role for this technique to
non-invasively assess fibrosis and inflammation in
patients with chronic liver disease at 3T. This might be
of clinical value in mentoring disease evolution and/or
response to therapy in these patients.
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