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Abstract #0379

Shear Wave Speed and Attenuation as Surrogate Imaging Biomarkers for the Quantification of Liver Fibrosis and Inflammation

Ahmed M. Gharib 1 , Simon Lambert 2 , Khaled Z. Abd-Elmoniem 1 , Ahmed A. Harouni 1 , Theo Heller 1 , Caryn Morse 1 , and Ralph Sinkus 3

1 National Institutes of Health, Bethesda, MD, United States, 2 Division of Imaging Sciences and Biomedical Engineering, Kings College, London, England, United Kingdom, 3 Division of Imaging Sciences and Biomedical Engineering, King's College, London, England, United Kingdom

Liver MR-elastography (MRE) was performed at 3T on 17 patients with known biopsy proven chronic liver disease. Shear wave speed and the shear wave attenuation were calculated at 26Hz and 58Hz. Both frequencies demonstrated increase shear wave speed that closely follows an increase in fibrosis. However, at 56Hz the shear wave attenuation strongly increases for fibrosis:inflammation ratio <1. This indicates a potential clinical role for this technique to non-invasively assess fibrosis and inflammation in patients with chronic liver disease at 3T. This might be of clinical value in mentoring disease evolution and/or response to therapy in these patients.

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