Abstract #0388
Unravel Neurochemical Contributions to Hemodynamic Responses using Simultaneous PET/MRI
Hsiao-Ying Wey 1 , Jacob M Hooker 1 , Bruce R Rosen 1 , and Joseph B Mandeville 1
1
A. A. Martinos Center for Biomedical
Imaging, Massachusetts General Hospital, Harvard Medical
School, Charlestown, MA, United States
Simultaneous PET/fMRI offers the unique opportunity to
relate neurochemical events to the functional changes
underlying neural activity. In this study, we present
simultaneous PET/fMRI study with pharmacological
challenges given to nonhuman primates to determine the
relationship between opioid receptor occupancy, dopamine
release, and changes in CBV. CBV-fMRI shows
dose-response to opioid agonist challenges. PET and fMRI
demonstrated concurrent signal changes overlapping in
the basal forebrain, such as the caudate, putamen, and
nucleus accumbens (NAc). In addition, the temporal
response of dopamine release matches a fast CBV decrease
in the NAc, while other brain regions show a slow CBV
increase comparable to the temporal dynamic of opioid
receptor binding.
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