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Abstract #0389

Baseline occipital perfusion inversely correlates with GABA after accounting for arterial arrival time discrepancies

Manus Donahue 1 , Swati Rane 1 , Erin Hussey 1 , Emily Mason 1 , Subechhya Pradhan 1 , Kevin Waddell 1 , and Brandon Ally 1

1 Vanderbilt University, Nashville, TN, United States

MRS measurements of the primary inhibitory neurotransmitter, GABA, and MRI measurements of CBF, fractional gray matter volume, and arterial arrival time (AAT) are recorded in human visual cortex from adult male volunteers. The primary finding is that occipital GABA derived from J-edited MEGA-PRESS inversely correlates with CBF in the same region. This finding provides some physiological basis for the reported inverse relationships between BOLD responses and GABA. A secondary finding is that AAT does not correlate strongly with GABA, but failure to account for AAT in ASL measurements can reduce or eliminate the detectability of CBF-GABA relationships.

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