Abstract #0391
The physical basis of inhomogeneous magnetization transfer
Scott D. Swanson 1 , David C. Alsop 2,3 , and Dariya I. Malyarenko 1
1
Department of Radiology, University of
Michigan, Ann Arbor, MI, United States,
2
Beth
Israel Deaconess Med. Ctr, Boston, MA, United States,
3
Radiology,
Harvard Medical School, Boston, MA, United States
Recent studies have shown that inhomogeneous
magnetization transfer (ihMT) can be created in white
matter and certain lipid systems by RF saturation at +/-
off-resonance frequencies. This work reports on
observation of MT and ihMT as a function of temperature
in model lipid systems. Our results show that the
structure and dynamics of lipids at low temperatures
create ihMT which decreases with increasing temperature
and is gradually converted into conventional MT by 65
C. Both MT and ihMT disappear as the sample melts at
the 85 C. A consistent theoretical explanation of ihMT
nature is provided in terms of selective dipolar
dynamics in model lipid systems.
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