Towards Understanding the Anisotropy of Magnetization Transfer Parameters in Human White Matter

We examine the apparent dependence of qMT parameters, in particular those of the T2 relaxation time of bound protons, on the white matter fiber orientation. It is found that those dependency results from parameter fitting using the Super-Lorentzian lineshape, which renders orientational dependency on other qMT parameters. A novel RF absorption lineshape of the bound pool considering the liquid-crystalline character of the myelin sheath is derived that explains this dependence. Data simulated using this lineshape were analyzed by parameter fitting. A remarkable agreement was found in the obtained parameters compared to those found in WM regions with fractional anisotropy FA>0.7.

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