Abstract #0393
Combined NODDI and qMT for full-brain g-ratio mapping with complex subvoxel microstructure
Jennifer S.W. Campbell 1 , Nikola Stikov 1 , Robert F. Dougherty 2 , and G. Bruce Pike 1,3
1
McConnell Brain Imaging Centre, McGill
University, Montreal, Quebec, Canada,
2
Stanford
Center for Neurobiological Imaging, Stanford University,
Stanford, California, United States,
3
Hotchkiss
Brain Institute, University of Calgary, Calgary,
Alberta, Canada
The myelin g-ratio is a fundamental metric that can be
computed from combined diffusion and quantitative
magnetization transfer (qMT) imaging. The g-ratio is a
function of the fiber volume fraction (FVF) and the
myelin volume fraction (MVF). The FVF may be obtained
from diffusion tensor imaging, but only in the case
where the MRI voxels contain a single fiber system with
parallel, straight fibers, making the FA an unsuitable
measure of FVF for full-brain quantitative maps. Here,
we apply the Neurite Orientation Dispersion and Density
Imaging (NODDI) model to obtain full brain g-ratio maps.
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