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Abstract #0394

Quantifying the contribution of white matter microstructure to frequency contrast in gradient echo MRI

Samuel Wharton 1 and Richard Bowtell 1

1 Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom

In most studies involving GE phase imaging, it is assumed that the dominant source of phase contrast is the variation in magnetic susceptibility across different tissues. Recent studies have suggested that white matter microstructure may be an additional source of phase contrast. In this study, we quantify the frequency contribution of white matter microstructure in a small tissue phantom by using sophisticated simulation techniques to model and remove the frequency contribution of bulk isotropic and anisotropic magnetic susceptibility. This approach also yields accurate estimates of the isotropic (-82 ppb) and anisotropic (11 ppb) susceptibility of white matter.

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