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Abstract #0420

Velocity-Selective Inversion Prepared Arterial Spin Labeling for 3D Whole-Brain Perfusion Measurment

Qin Qin 1,2 and Peter C.M. van Zijl 1,2

1 Radiology, Johns Hopkins University, Baltimore, Maryland, United States, 2 Kirby Center, Kennedy Krieger Institute, Baltimore, Maryland, United States

A novel velocity-selective inversion pulse preparation is developed based on the k-space formalism, which is robust to B0/B1 inhomogeneity and eddy currents by embedding a pair of adiabatic pulses for refocusing in each k-segment. This new pulse, dubbed Double-Refocused Inversion with Velocity Encoding (DRIVE), is applied to velocity-selective Arterial Spin Labeling (VSASL) for cerebral blood flow (CBF) measurement at 3T. We performed VSASL using the DRIVE pulse train and a standard Pseudo-Continuous ASL (PCASL) with 3D whole-brain acquisition for comparison. The results show excellent agreement between the two methods in both CBF quantification and SNR level.

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