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Abstract #0421

White Matter Perfusion Measurement using Velocity-Selective Arterial Spin Labeling A Comparison with Pulsed ASL and Pseudo-Continuous ASL

Jia Guo 1 and Eric C. Wong 2

1 Department of Bioengineering, University of California San Diego, La Jolla, California, United States, 2 Departments of Radiology and Psychiatry, University of California San Diego, La Jolla, California, United States

It is challenging to measure WM CBF using ASL due to the low WM CBF and the heterogeneous and long transit delays. VSASL is inherently insensitive to transit delays, but for typical parameters it has a lower SNR than conventional ASL methods such as PCASL. However, compared with PCASL in which a long PLD was required in WM measurements, VSASL with two Velocity Selective Saturation (VSS) modules provided a comparable SNR (P=0.52) and CBF values (P=0.61) in WM, and even had a higher SNR in GM (P<0.01). VSASL may be more favorable than other tagging methods in applications where long transit delays are expected.

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