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Abstract #0446

Resting State fMRI in the moving fetus: a robust framework for motion and spin history correction.

Giulio Ferrazzi 1,2 , Maria Kuklisova Murgasova 1,2 , Tom Arichi 3 , Joanna Allsop 1,2 , Christina Malamateniou 1,2 , Mary Rutherford 1,2 , Shaihan Malik 1,2 , Paul Aljabar 1,2 , and Joseph V. Hajnal 1,2

1 Center for the Developing Brain, King's College London, London, United Kingdom, 2 Division of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom, 3 Department of Bioengineering, Imperial College London, London, United Kingdom

During typical fetal Resting State fMRI examinations, maternal respiration and fetal movement together result in large scale and unpredictable motion. Conventional fMRI processing methods, which assume that brain movements are infrequent or at least small, are not suitable. We seek to address the problem of fetal motion in fMRI using image registration to place the acquired data into a self-consistent anatomical space. Bias field and spin history corrections are also discussed, aiming at achieving a robust framework that allows as much as possible, ideally all acquired data, to be retained as part of the final network analysis.

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