Abstract #0447
Developing 3D Wavefield Renal MR Elastography: Primary Hyperoxaluria Pilot Study
Scott A. Kruse 1 , Kevin J. Glaser 1 , Jun Chen 1 , Dawn S. Milliner 2 , Sudhakar K. Venkatesh 1 , and Richard L. Ehman 1
1
Department of Radiology, Mayo Clinic,
Rochester, Minn., United States,
2
Division
of Nephrology and Hypertension, Mayo Clinic, Rochester,
Minn., United States
There is a clinical need for more effective noninvasive
tools for assessing the extent of renal parenchymal
disease. MR Elastography has been shown to be effective
in staging hepatic fibrosis. Here we developed a 3D
wavefield protocol for applying MRE to the kidneys. Four
normal volunteers and five patient volunteers with
primary hyperoxaluria were enrolled. The mean renal
parenchymal stiffness for the normal volunteers was 2.99
+ 1.08 kPa at 60 Hz. In addition, the patient results
provide preliminary evidence of a trend of decreased
parenchymal stiffness with increasing urinary oxalate
levels.
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