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Abstract #0447

Developing 3D Wavefield Renal MR Elastography: Primary Hyperoxaluria Pilot Study

Scott A. Kruse 1 , Kevin J. Glaser 1 , Jun Chen 1 , Dawn S. Milliner 2 , Sudhakar K. Venkatesh 1 , and Richard L. Ehman 1

1 Department of Radiology, Mayo Clinic, Rochester, Minn., United States, 2 Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minn., United States

There is a clinical need for more effective noninvasive tools for assessing the extent of renal parenchymal disease. MR Elastography has been shown to be effective in staging hepatic fibrosis. Here we developed a 3D wavefield protocol for applying MRE to the kidneys. Four normal volunteers and five patient volunteers with primary hyperoxaluria were enrolled. The mean renal parenchymal stiffness for the normal volunteers was 2.99 + 1.08 kPa at 60 Hz. In addition, the patient results provide preliminary evidence of a trend of decreased parenchymal stiffness with increasing urinary oxalate levels.

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