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Abstract #0448

High resolution mechanical imaging of the human kidney

Jing Guo 1 , Kaspar-Josche Streitberger 1 , Heiko Tzschaetzsch 1 , Sebastian Hirsch 1 , Juergen Braun 2 , and Ingolf Sack 1

1 Department of Radiology, Charite - Universitaetsmedizin Berlin, Berlin, Berlin, Germany, 2 Department of Medical Informatics, Charite - Universitaetsmedizin Berlin, Berlin, Germany

Renal fibrosis can be detected by MR elastography (MRE) based on altered mechanical tissue properties. However, MRE has been limited in providing high resolution mechanical parameter maps of the kidney due to low-resolution shear wave images and ill-posed solutions of the inverse problem of MRE. We here overcome both problems by an optimized single shot MRE sequence and multifrequency dual elasto visco inversion. As a result, high resolution MRE maps are obtained which for the first time enable radiologists to analyze the regional variation of the kidney's viscoelastic properties on a pixel-to-pixel base.

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