Abstract #0449
A two-compartment model with automatic time interval selection for estimation of GFR using DCE-MRI in cohort of 28 survivors of unilateral Wilms tumor
Aaryani Tipirneni-Sajja 1,2 , Ralf B Loeffler 1 , Niels Oesingmann 3 , Yutong Duan 1 , Adam M Winchell 1,2 , Ruitian Song 1 , Beth McCarville 1 , Melissa Hudson 4 , Sherri L Spunt 4 , and Claudia M Hillenbrand 1
1
Radiological Sciences, St. Jude Children's
Research Hospital, Memphis, TN, United States,
2
Biomedical
Engineering, University of Memphis, Memphis, TN, United
States,
3
Siemens
Medical Solutions USA, Inc, New York, NY, United States,
4
Oncology,
St. Jude Children's Research Hospital, Memphis, TN,
United States
Renal GFR is a very important quantitative index of
renal function in health and disease. Several methods
are available to estimate GFR using DCE-MRI, but a
precise and unbiased method to estimate GFR remains to
be developed. This study estimates GFR by DCE-MRI using
a two-compartment (2C) model that disregards tubular
outflow and automatically picks the end-of-uptake point
(auto2C) and compares these results with those from the
gold standard GFR measurement (99mTc-DTPA) in long-term
survivors of unilateral Wilms tumor.
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