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Abstract #0454

Multiparametric functional MRI for assessment of delayed renal allograft function

Dagmar Hartung 1,2 , Marcel Gutberlet 1,2 , Frank Lehner 2,3 , Nicolas Richter 3 , Nils Hanke 4 , Jan Becker 2,5 , Matti Peperhove 1 , Antonia Zapf 6 , Hermann Haller 4 , Frank Wacker 1 , Wilfried Gwinner 2,4 , and Katja Hueper 1,2

1 Radiology, Hannover Medical School, Hannover, Germany, 2 Integrated Research and Treatment Center Transplantation (IFB Tx), Hannover, Germany, 3 Transplantation Surgery, Hannover Medical School, Hannover, Germany, 4 Nephrology, Hannover Medical School, Hannover, Germany, 5 Pathology, Hannover Medical School, Hannover, Germany, 6 Medical Statistics, University Goettingen, Goettingen, Germany

Delayed renal allograft function (DGF) is associated with an increased risk of graft complications. We investigated whether multiparametric functional MRI allows evaluation of DGF. Fourty patients between day 4-10 after kidney transplantation were examined using a 1.5T-scanner. Renal perfusion, apparent diffusion coefficients and fractional anisotropy were significantly reduced in patients with DGF compared to patients with normal initial graft function. Furthermore, functional MRI parameters were inversely correlated with serum creatinine at the day of MRI and at 3-months follow-up. Thus, multiparametric functional MRI may improve non-invasive diagnosis of DGF.

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