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Abstract #0455

Detailing the Relation Between Renal T2* and Renal Tissue pO2 Using a Hybrid and Integrated Approach of Parametric MRI and Invasive Physiological Measurements (MR-PHYSIOL)

Andreas Pohlmann 1 , Jan Hentschel 1 , Karen Arakelyan 1 , Kathleen Cantow 2 , Bert Flemming 2 , Mechthild Ladwig 2 , Uwe Hoff 3 , Erdmann Seeliger 2 , and Thoralf Niendorf 1

1 Berlin Ultrahigh Field Facility, Max Delbrueck Center for Moleculare Medicine, Berlin, Germany, 2 Institute of Physiology and Center for Cardiovascular Research, Charit Medical Faculty, Berlin, Germany, 3 Nephrology and Intensive Care Medicine, Campus Virchow-Klinikum and Center for Cardiovascular Research, Charite-Universitaetsmedizin Berlin, Berlin, Germany

Acute kidney injuries of various origins share one common feature: imbalance between renal oxygen delivery and demand. T2* mapping offers a non-invasive approach to probe renal oxygenation. Changes in tissue pO2 and T2* may be closely related but for a physiological interpretation of T2* a calibration using an integrative approach that combines parametric MR with physiological measurements is prudent if not essential. This work employs an integrative hybrid approach that combines established invasive but quantitative techniques with a small animal MR system (MR-PHYSIOL) with the ultimate goal to detail the relation between tissue pO2 and T2* using (patho)physiologically relevant interventions.

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