Event-related dynamics of glutamate and BOLD signal at 3 T in a repetition suppression paradigm

Improvements in scanner technologies and data acquisition and analysis methods allow magnetic resonance spectroscopy (MRS) techniques to detect neurochemical concentration changes associated with neural activity. This functional MRS (fMRS) technique is gaining increasing interest in neuroscience, however a debate exists as to whether stimulus related changes of metabolites might be reliably detected using fMRS, and if it is possible to do so at 3T. This study presents event related dynamics of glutamate (Glu) and blood-oxygen-level-dependent (BOLD) signal at 3T in a repetition suppression paradigm.

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