Assessing Activation Induced Changes in Creatine Kinase Activity in the Human Brain using 31P Spectroscopy with Magnetisation Transfer

31P magnetic spectroscopy with magnetisation transfer was used to investigate changes in creatine kinase (CK) kinetics induced in human visual cortex during visual stimulation by measuring the unidirectional PCr->ATP rate constant (k1). Results revealed that 1) intrinsic and apparent spin-lattice relaxation time T1 of PCr at 3T are 4.670.91s and 1.510.18s, respectively; 2) k1 increased by 17 12 % during visual stimulation, indicating that CK turnover is elevated during increased neuronal activity.

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