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Abstract #0465

Changes in cerebral physiology with ageing assessed by respiratory-calibrated MRI

Michael Kelly 1,2 , Hannah Hare 1 , Michael Germuska 1 , Nicola Filippini 1 , and Daniel Bulte 1

1 FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, United Kingdom, 2 Centre for Core Biotechnology Services, University of Leicester, Leicester, Leicestershire, United Kingdom

Recently, respiratory-calibrated MRI methods capable of providing a quantitative assessment of cerebral physiology have been developed. In this study, respiratory-calibrated MRI was applied to healthy aged subjects to investigate the effect of potentially altered baseline physiology on the parameters quantified by respiratory-calibrated MRI. The parameters were not found to correlate with physiological parameters such as age, blood pressure, BMI and pulse rate. Oxygen extraction fraction and cerebral blood flow (CBF) were found be inversely correlated and cerebrovascular reactivity and CBF were positively correlated. These findings are in agreement with recent PET studies and provide validation of respiratory-calibrated MRI methods.

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