Abstract #0465
Changes in cerebral physiology with ageing assessed by respiratory-calibrated MRI
Michael Kelly 1,2 , Hannah Hare 1 , Michael Germuska 1 , Nicola Filippini 1 , and Daniel Bulte 1
1
FMRIB Centre, Nuffield Department of
Clinical Neurosciences, University of Oxford, Oxford,
Oxfordshire, United Kingdom,
2
Centre
for Core Biotechnology Services, University of
Leicester, Leicester, Leicestershire, United Kingdom
Recently, respiratory-calibrated MRI methods capable of
providing a quantitative assessment of cerebral
physiology have been developed. In this study,
respiratory-calibrated MRI was applied to healthy aged
subjects to investigate the effect of potentially
altered baseline physiology on the parameters quantified
by respiratory-calibrated MRI. The parameters were not
found to correlate with physiological parameters such as
age, blood pressure, BMI and pulse rate. Oxygen
extraction fraction and cerebral blood flow (CBF) were
found be inversely correlated and cerebrovascular
reactivity and CBF were positively correlated. These
findings are in agreement with recent PET studies and
provide validation of respiratory-calibrated MRI
methods.
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