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Abstract #0476

Hyperpolarized [1- 13 C] glutamate: a surrogate marker of IDH1 mutational status in glioblastoma

Myriam M Chaumeil 1 , Peder E.Z. Larson 1 , Sarah M Woods 1 , Pia Eriksson 1 , Larry Cai 1 , Aaron Robinson 2 , Daniel B Vigneron 1 , Sarah J Nelson 1 , Russell O Pieper 2 , Joanna J Phillips 2 , and Sabrina M Ronen 1,2

1 Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2 Brain Tumor Research Center, UCSF, San Francisco, CA, United States

Following injection of hyperpolarized α-ketoglutarate, we previously reported the detection of hyperpolarized 2-hydroxyglutarate formation in IDH1-mutant tumors, not in in IDH1 wild-type, using 2D 13 C dynamic CSI at clinical field strength. Here, we show that, contrarily to 2-hydroxyglutarate, hyperpolarized glutamate formation from hyperpolarized α-ketoglutarate could be detected in IDH1 wild-type perfused cells and tumors only, not in cells or tumors harboring the IDH1 mutation. Biochemical assays were performed to assess the underlying mechanisms. Hyperpolarized glutamate could thus potentially serve as a non-invasive additional surrogate marker of IDH1 mutational status in brain tumors.

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