Abstract #0480
Preliminary Study of Cerebral NAD Metabolism and Redox State in Parkinsons Patients
Xiao-Hong Zhu 1 , Byeong-Yeul Lee 1 , Susan Rolandelli 2 , Ming Lu 1 , Paul Tuite 2 , and Wei Chen 1
1
CMRR, Department of Radiology, University of
Minnesota Medical School, Minneapolis, MN, United
States,
2
Department
of Neurology, University of Minnesota Medical School,
MN, United States
Energy failure from mitochondrial dysfunction has been
proposed as a central mechanism leading to neuronal
death in a range of neurodegenerative diseases. However,
it is difficult to evaluate the link between abnormal
energetics and impaired mitochondrial functions
associated with neurodegeneration in living human brain.
Recently a new high-field
in
vivo
31
P
MRS approach has been developed and its capability for
non-invasively assessing the intracellular nicotinamide
adenine dinucleotide (NAD) contents and its redox ratio
has been demonstrated in healthy human brain at 7T. In
the present study, we applied this newly developed
method for quantitative assessment and comparison of NAD
redox state in Parkinsons disease (PD) patients and
matched controls. The preliminary findings demonstrated
abnormal cerebral energy metabolism associated with PD
and the potential influences of gender in the disease.
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