Abstract #0479
3D GABA imaging with high spatial resolution at 3T using a navigated MEGA-LASER MRSI sequence
Wolfgang Bogner 1 , Borjan Gagoski 2 , Aaron T Hess 3 , Bernhard Strasser 1 , Himanshu Bhat 4 , Dylan Tisdall 5 , Andre J.W. van der Kouwe 5 , Ellen Grant 2 , Siegfried Trattnig 1 , Bruce Rosen 5 , and Ovidiu C Andronesi 5
1
High-field MR Center, Department of
Biomedical Imaging and Image-guided Therapy, Medical
University Vienna, Vienna, Vienna, Austria,
2
Fetal-Neonatal
Neuroimaging & Developmental Science Center, Boston
Children's Hospital, Harvard Medical School, Boston,
United States,
3
Department
of Cardiovascular Medicine, John Radcliffe Hospital,
University of Oxford Centre for Clinical Magnetic
Resonance Research, Oxford, United Kingdom,
4
Siemens
Healthcare, Charlestown, United States,
5
Athinoula
A. Martinos Center for Biomedical Imaging, Department of
Radiology, Massachusetts General Hospital, Harvard
Medical School, Charlestown, United States
GABA, the major inhibitory neurotransmitters, is
difficult to detect. Single-voxel MEscher-GArwood (MEGA)
PRESS editing MRS is the most popular technique for
non-invasive detection of GABA, but it has several
limitations: MEGA editing is a subtraction technique
and, therefore, prone to scanner instabilities and
motion artifacts. Chemical shift displacement errors (CSDE)
in PRESS reduce editing efficiency. Single-voxel
localization does not allow the characterization of
spatial concentration differences. Therefore, our study
introduces a robust MEGA-editing 3D-CSI sequence for 3T
that uses LASER localization to eliminate CSDE; spiral
encoding to accelerate acquisition; and real-time
motion-/B0-correction with selective data reacquisition
to eliminate subtraction artifacts.
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