Regional variations of GABA, glutamate, glutamine and NAAG in the human brain, as measured by 1H MRS at 7T in vivo

We report regional variations in metabolite levels in healthy human brain, focusing on GABA, glutamate, glutamine, and N-acetyl-aspartyl-glutamate. A GABA-tailored PRESS sequence (TE = 92 ms) was used, at 7T, to measure the metabolites in gray matter (GM) and white matter (WM) dominant regions in the frontal and occipital brain in 9 healthy volunteers. Metabolite levels in pure GM and WM were obtained with linear regression of metabolite estimates vs. fractional GM contents. The result indicated that the concentrations of many metabolites are significantly different between frontal and occipital brain as well as between GM and WM.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.