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Abstract #0483

Effects of APOE - 4, Age and HIV on Glial Metabolite and Cognitive Deficits

Linda Chang 1 , Caroline S. Jiang 1 , Eric Cunningham 1 , Steven Buchthal 1 , Vanessa Douet 1 , Marilou Andres 2 , and Thomas Ernst 1

1 Department of Medicine, University of Hawaii at Manoa, John A. Burns School of Medicine, Honolulu, Hawaii, United States, 2 University of Hawaii at Manoa, Pacific Biosciences Research Center, Honolulu, Hawaii, United States

Despite effective antiretroviral medications, milder forms of HIV-associated neurocognitive disorders (HAND) remain prevalent. The apolipoprotein-E( APOE )- lower case Greek epsilon 4 gene was inconsistently found to increase the risk for HAND. Whether HIV subjects with APOE )- lower case Greek epsilon 4 allele(s) would show greater neuroinflammation, which may contribute to cognitive deficits, is unknown and was evaluated. 177 participants (97 seronegative controls and 80 HIV subjects) were evaluated with 1 H MRS, cognitive assessments and genotyping for APOE . HIV subjects showed elevated levels of myoinositol regardless of APOE - lower case Greek epsilon 4 genotype and across the agespan, which was associated with poorer cognitive function. APOE - lower case Greek epsilon 4 combined with 1 H MRS may be useful markers to predict HAND.

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