Abstract #0483

Effects of APOE - 4, Age and HIV on Glial Metabolite and Cognitive Deficits

Linda Chang ¹ , Caroline S. Jiang ¹ , Eric Cunningham ¹ , Steven Buchthal ¹ , Vanessa Douet ¹ , Marilou Andres ² , and Thomas Ernst ¹

¹ Department of Medicine, University of Hawaii at Manoa, John A. Burns School of Medicine, Honolulu, Hawaii, United States, ² University of Hawaii at Manoa, Pacific Biosciences Research Center, Honolulu, Hawaii, United States

Despite effective antiretroviral medications, milder forms of HIV-associated neurocognitive disorders (HAND) remain prevalent. The apolipoprotein-E( APOE )- lower case Greek epsilon

4 gene was inconsistently found to increase the risk for HAND. Whether HIV subjects with APOE )- lower case Greek epsilon

4 allele(s) would show greater neuroinflammation, which may contribute to cognitive deficits, is unknown and was evaluated. 177 participants (97 seronegative controls and 80 HIV subjects) were evaluated with ¹ H MRS, cognitive assessments and genotyping for APOE . HIV subjects showed elevated levels of myoinositol regardless of APOE - lower case Greek epsilon

4 genotype and across the agespan, which was associated with poorer cognitive function. APOE - lower case Greek epsilon

4 combined with ¹ H MRS may be useful markers to predict HAND.

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