Abstract #0484
Detection of Metabolite Changes in Response to a Varying Visual Stimulation Paradigm Using Short TE 1 H MRS at 7T
Ralf Mekle 1 , Simone Kuehn 2 , Harald Pfeiffer 1 , Florian Schubert 1 , and Bernd Ittermann 1
1
Medical Physics, Physikalisch-Technische
Bundesanstalt, Berlin, Germany,
2
Center
for Lifespan Psychology, Max Planck Institute for Human
Development, Berlin, Germany
The goal of this study was to detect differences in
steady-state metabolite levels in response to a varying
stimulation paradigm in the right human visual cortex
using short TE
1
H
MRS methodology at 7T. Instead of a strict on/off
paradigm, where global physiologic effects might
adversely influence MRS data acquisition, a modified
stimulation condition not affecting the target voxel was
employed as baseline. Nineteen metabolites were reliably
quantified. A reduction of the neurotransmitter GABA and
an increase of lactate were observed as the only
significant effects. Differences with previous studies
were attributed to the modified experimental conditions.
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