In vivo measurements of acute pain induced changes of GABA+ and Glx in the brain by using functional 1 H-MEGA-PRESS MR spectroscopy

: This study comprises results of time resolved measurements of acute heat pain induced changes in excitatory (Glx) and inhibitory (GABA+) neurotransmitter turnover in the aCC by using 1H-MEGA-PRESS spectroscopy. Compared to the reference condition Glx/tCr increased significantly up to a median value of 14.2% in aCC during stimulation. At the same time, GABA+/tCr decreased by a median value of 25.4%. The Glx/tCr increase may be ascribed to the elevated glutamatergic turnover, while the GABA+/tCr decrease may reflect reduced activity of the inhibitory system during pain processing.

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