Abstract #0486
Medial temporal lobe hypointense foci in Alzheimers disease reflects accumulation of iron-containing microglia.
Michael Zeineh 1 , Hannes Vogel 2 , Yuanxin Chen 3 , Hagen Kitzler 4 , Scott Atlas 2 , and Brian Rutt 2
1
Radiology, Stanford University, Stanford,
CA, United States,
2
Stanford
University, Stanford, California, United States,
3
Robarts
Research Institute, Ontario, Canada,
4
Universittsklinikum
Carl Gustav Carus an der Technischen Universitt
Dresden, Germany
Hypointense foci in the medial temporal lobe may reflect
Alzheimers pathology. To discern the etiology of iron
accumulation in Alzheimers disease, we performed
high-resolution GRE imaging at 7.0T of AD specimens. We
registered and evaluated concurrent DAB-iron,
CD163-microglia, and beta-amyloid stains of the same
specimens. Iron containing foci best explained the MR
hypointense foci that accumulated at and along the
undersurface of the CA1/subiculum junction. This iron
was primarily localized within microglia, not amyloid
plaques.
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