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Abstract #0486

Medial temporal lobe hypointense foci in Alzheimers disease reflects accumulation of iron-containing microglia.

Michael Zeineh 1 , Hannes Vogel 2 , Yuanxin Chen 3 , Hagen Kitzler 4 , Scott Atlas 2 , and Brian Rutt 2

1 Radiology, Stanford University, Stanford, CA, United States, 2 Stanford University, Stanford, California, United States, 3 Robarts Research Institute, Ontario, Canada, 4 Universittsklinikum Carl Gustav Carus an der Technischen Universitt Dresden, Germany

Hypointense foci in the medial temporal lobe may reflect Alzheimers pathology. To discern the etiology of iron accumulation in Alzheimers disease, we performed high-resolution GRE imaging at 7.0T of AD specimens. We registered and evaluated concurrent DAB-iron, CD163-microglia, and beta-amyloid stains of the same specimens. Iron containing foci best explained the MR hypointense foci that accumulated at and along the undersurface of the CA1/subiculum junction. This iron was primarily localized within microglia, not amyloid plaques.

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