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Abstract #0487

Neuropathologic correlates of regional brain volumes assessed with ex-vivo MRI.

Aikaterini Kotrotsou 1 , David A. Bennett 2 , Julie A. Schneider 2 , Sue E. Leurgans 2 , Tom Golak 1 , and Konstantinos Arfanakis 1,2

1 Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, United States, 2 Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States

Brain atrophy is considered a biomarker of Alzheimer's disease (AD) pathology. However, mixed pathologies are common in the elderly, and several of them may lead to atrophy. Also, only a handful of studies with low numbers of participants have combined brain MR volumetry with measures of neuropathology obtained after death. Thus, the relation between brain atrophy and age-related neuropathology is actually not well-established. The purpose of this investigation was to assess the neuropathologic correlates of regional brain volumes by combining ex-vivo MR volumetry and pathology information on a large community cohort of older persons.

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