Abstract #0491
Rapamycin Restores Cerebral Blood Flow and Blood Brain Barrier Integrity in APOE4 Carriers
Ai-Ling Lin 1,2 , Wei Zhang 1 , and Arlan Richardson 2
1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
TX, United States,
2
Cellular
& Structural Biology, University of Texas Health Science
Center at San Antonio, San Antonio, TX, United States
In the study, we used multi-metric MRI methods to
evaluate the treatment efficacy of rapamycin on
cerebrovascular functions in mice expressing the human
e4 allele of the apolipoprotein E gene (APOE4), which is
a risk factor for Alzheimers disease (AD). We found
that young APOE4 mice treated with rapamycin had
significantly restored cerebral blood flow and blood
brain barrier integrity compared to the non-treated
group, and the effects were prominent over time. The
restored cerebrovascular functions in the APOE4 mice
resembled those of age-matched wild-type mice. Our
results suggest that rapamycin would be promising for
future treatment/prevention of AD.
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