Abstract #0492
Sub-regional Hippocampus Glutamate Changes in a Mouse Model of Tau Pathology Measured by GluCEST
Rachelle Crescenzi 1,2 , Catherine DeBrosse 1,2 , Ravi Prakash Reddy Nanga 2 , Hari Hariharan 2 , Ari Borthakur 2 , John Detre 3 , Virginia M.-Y. Lee 4 , and Ravinder Reddy 2
1
Biochemistry and Molecular Biophysics,
University of Pennsylvania, Philadelphia, PA, United
States,
2
Center
for Magnetic Resonance and Optical Imaging (CMROI),
University of Pennsylvania, Philadelphia, PA, United
States,
3
Center
for Functional Neuroimaging (CfN), University of
Pennsylvania, Philadelphia, PA, United States,
4
Center
for Neurodegenerative Disease Research (CNDR),
University of Pennsylvania, Philadelphia, PA, United
States
Synapse loss is the main correlate of cognitive defecits
in AD. Here, synapse loss in the sub-regions of the
hippocampus of the P301S tauopathic mouse brain is shown
to correlate with glutamate loss measured by GluCEST:
glutamate chemical exchange saturation transfer. Average
GluCEST is decreased in the thalamus/hypo-thalamus and
CA sub-region of the hippocampus, yet maintained in the
dentate gyrus. Immunohistochemistry confirms that
synapse loss occurs throughout the transgenic brain,
except in the DG where neurons are known to be
regenerated. GluCEST imaging allows the DG neuronal
integrity to be observed in vivo, which was not possible
using conventional spectroscopy.
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