Meeting Banner
Abstract #0493

Perfusion and vascular response as early markers in a bigenic mouse model of Alzheimers Disease

Kristof Govaerts 1 , Uwe Himmelreich 1 , Fred Van Leuven 2 , and Tom Dresselaers 1

1 Imaging & Pathology, KU Leuven, Leuven, Vlaams-Brabant, Belgium, 2 Human Genetics, KU Leuven, Leuven, Vlaams-Brabant, Belgium

Tempoparietal hypoperfusion is an early symptom of Alzheimers Disease (AD). Recent studies in AD and mild cognitive impairment (MCI) patients also suggest that the cerebrovascular response to hypercapnia (CVR) may be a more sensitive readout. We performed arterial spin labeling to determine cerebral blood flow increases in response to a hypoventilation-induced hypercapnic challenge in a bigenic biAT mice, a model for AD. We report decreased basal perfusion already at young age (3 months), as well as a significantly increased CVR in response to hypoventilation-induced hypercapnia.

This abstract and the presentation materials are available to members only; a login is required.

Join Here