Abstract #0493
Perfusion and vascular response as early markers in a bigenic mouse model of Alzheimers Disease
Kristof Govaerts 1 , Uwe Himmelreich 1 , Fred Van Leuven 2 , and Tom Dresselaers 1
1
Imaging & Pathology, KU Leuven, Leuven,
Vlaams-Brabant, Belgium,
2
Human
Genetics, KU Leuven, Leuven, Vlaams-Brabant, Belgium
Tempoparietal hypoperfusion is an early symptom of
Alzheimers Disease (AD). Recent studies in AD and mild
cognitive impairment (MCI) patients also suggest that
the cerebrovascular response to hypercapnia (CVR) may be
a more sensitive readout. We performed arterial spin
labeling to determine cerebral blood flow increases in
response to a hypoventilation-induced hypercapnic
challenge in a bigenic biAT mice, a model for AD. We
report decreased basal perfusion already at young age (3
months), as well as a significantly increased CVR in
response to hypoventilation-induced hypercapnia.
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