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Abstract #0494

New tools for amyloid plaques detection by MRI: Gadolinium-VHH antibody conjugates

Matthias Vandesquille 1,2 , Tengfei Li 2,3 , Chrystelle Po 1 , Christelle Ganneau 2 , Christian Czech 4 , Charles Duyckaerts 3 , Benot Delatour 3 , Sylvie Bay 2 , Pierre Lafaye 2 , and Marc Dhenain 1

1 MIRCen, CEA, Fontenay-aux-Roses, France, 2 Institut Pasteur, Paris, France, 3 ICM, Hpital de la Piti-Salptrire, Paris, France, 4 Hoffmann-La Roche, Basel, Switzerland

Amyloid deposits occur many years before neuropsychological symptoms of Alzheimer's disease. Their detection by MRI is thus critical. We designed a contrast agent combining the properties of VHH antibodies and gadolinium to specifically label amyloid plaques by MRI. We showed that hypointense spots were observed on T2* images following in vitro incubation or in vivo ICV injection of the VHH-DOTA/Gd. Several spots were colocalized with the amyloid plaques revealed by a reference (Gold-standard) Gd-staining procedure. Overall, this study describes a new promising tool for the detection of amyloid deposits by MRI.

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