Abstract #0495
Hypoperfusion signature in healthy subjects in risk of developing Alzheimer's Disease
Pablo Garcia-Polo 1,2 , Virginia Mato 1,3 , Daniel Garcia-Frank 1,4 , Norberto Malpica 1 , Juan Alvarez-Linera 5 , and Juan Antonio Hernandez-Tamames 2,3
1
LAIMBIO-DTE, Universidad Rey Juan Carlos,
Mostoles, Madrid, Spain,
2
Center
for Biomedical Technology U.P.M., Pozuelo de Alarcon,
Madrid, Spain,
3
Center for Alzheimer's Disease
Queen Sofia Foundation CIEN Foundation, Madrid, Madrid,
Spain,
4
IdiPAZ,
Madrid, Spain,
5
Hospital
Ruber Internacional, Madrid, Spain
This work analyses structural and physiological features
in a healthy population (25 subjects, PAD group) in risk
of developing Alzheimer's disease (left and right
hippocampus mean-2std.) the asl technique provides
perfusion maps that, after normalization and partial
volume effect correction steps, are studied through a
two-sample t-test (25 subjects control group). also,
segmented 3dt1w images with vbm-dartel. pad, as
expected, suffer from grey matter loss in both
hippocampi and, additionally, hypoperfusion hippocampi,
amygdala entorhinal cortex. we propose to include
studies, more sensitive than structural vbm, standard
research criteria for early diagnosis of ad.
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