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Abstract #0512

Quantitative Vessel-Encoded Arterial Spin Labeling Reveals Collateral Blood Flow in Hyper-Acute Stroke Patients

Thomas W Okell 1 , George WJ Harston 2 , Michael A Chappell 3 , Fintan Sheerin 4 , Martino Cellerini 4 , Stephen J Payne 3 , James Kennedy 5 , and Peter Jezzard 1

1 FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, United Kingdom, 2 Nuffield Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom, 3 IBME, Department of Engineering Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom, 4 Department of Neuroradiology, Oxford University Hospitals NHS Trust, Oxford, Oxfordshire, United Kingdom, 5 Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom

Multi-postlabeling delay vessel-encoded arterial spin labeling is capable of generating artery specific quantitative maps of cerebral blood flow and bolus arrival time non-invasively and without contrast agent. This method was applied to serially study hyper-acute stroke patients. Changes in the vascular territories over time were observed, with collateral flow appearing to spare tissue from infarction. Significant delays to blood arrival were measured in regions around the perfusion deficit compared to the contralateral side. This technique shows promise for diagnosis, prognosis and understanding the pathophysiology of acute stroke.

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