Abstract #0511
Muscle-based pharmacokinetic model for bone marrow perfusion study
Heather T. Ma 1 , James F. Griffith 2 , Chenfei Ye 3 , Xinxin Zhao 4 , and David K. Yeung 2
1
Harbin Institute of Technology
Shenzhen Graduate School, Shenzhen, Guangdong,
China,
2
Department
of Imaging and Interventional Radiology, Prince
of Wales Hospital, The Chinese University of
Hong Kong, Shatin, Hong Kong,
3
Department
of Electronic and Information Engineering,
Harbin Institute of Technology Shenzhen Graduate
School, Shenzhen, Guangdong, China,
4
Department
of Electronic and Information Engineering,
Harbin Institute of Technology Shenzhen Graduate
School, Guangdong, China
This study characterized bone marrow perfusion
properties in a quantitative way by adopting
surrounding muscle as the reference. A
muscle-based pharmacokinetic model was
established by adapting a reference region-based
model in the bone marrow. Contrast agent
extravasation rate constants for bone marrow and
the extravascular-extracellular volume fractions
for muscle were observed to diminish with the
decreased bone mineral density (BMD), while
muscle perfusion indices had no significant
change among groups with different BMD. The
results indicated that the impaired perfusion
function is only a function of the bone marrow
and not of the adjacent musculature.
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