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Abstract #0519

The influence of computational strategy on prediction of MRI-based mechanical stress in carotid atherosclerotic plaques: comparison of 2D structure-only, 3D structure-only, one-way and fully coupled FSI analyses

Yuan Huang 1 , Zhongzhao Teng 1,2 , Umar Sadat 3 , and Jonathan H Gillard 1

1 University Department of Radiology, University of Cambridge, Cambridge, Cambridge, United Kingdom, 2 Department of Engineering, University of Cambridge, Cambridge, United Kingdom, 3 Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridge, United Kingdom

Plaque composition detected by imaging alone cannot accurately predict future cerebrovascular risk, and additional analyses or biomarkers are required. Under physiological conditions, carotid plaques are subjected to mechanical loading from pulsatile blood pressure. FC rupture may occur when this loading exceeds its material strength. Different computational strategies, including 2D structure-only, 3D structure-only, 3D one-way and fully coupled fluid-structure interaction (FSI), have been employed to examine plaque stress. This study indicated that 2D simulations yielded a poor performance in predicting stress and 3D structural-only models showed good qualitative and quantitative agreement with the 3D fully coupled FSI.

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