Abstract #0519
The influence of computational strategy on prediction of MRI-based mechanical stress in carotid atherosclerotic plaques: comparison of 2D structure-only, 3D structure-only, one-way and fully coupled FSI analyses
Yuan Huang 1 , Zhongzhao Teng 1,2 , Umar Sadat 3 , and Jonathan H Gillard 1
1
University Department of Radiology,
University of Cambridge, Cambridge, Cambridge, United
Kingdom,
2
Department
of Engineering, University of Cambridge, Cambridge,
United Kingdom,
3
Department
of Surgery, Cambridge University Hospitals NHS
Foundation Trust, Cambridge, Cambridge, United Kingdom
Plaque composition detected by imaging alone cannot
accurately predict future cerebrovascular risk, and
additional analyses or biomarkers are required. Under
physiological conditions, carotid plaques are subjected
to mechanical loading from pulsatile blood pressure. FC
rupture may occur when this loading exceeds its material
strength. Different computational strategies, including
2D structure-only, 3D structure-only, 3D one-way and
fully coupled fluid-structure interaction (FSI), have
been employed to examine plaque stress. This study
indicated that 2D simulations yielded a poor performance
in predicting stress and 3D structural-only models
showed good qualitative and quantitative agreement with
the 3D fully coupled FSI.
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