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Abstract #0520

Cerebral microinfarcts determined at 7T MRI are associated with a thin fibrous cap in ipsilateral carotid atherosclerotic plaque

Alexandra A.J. de Rotte 1 , Wouter Koning 2 , Anne G. den Hartog 3 , Sandra M. Bovens 4 , Aryan Vink 5 , Shahrzad Sepehrkhouy 5 , Jaco J.M. Zwanenburg 6 , Dennis W.J. Klomp 6 , Gerard Pasterkamp 7 , Frans L. Moll 3 , Peter L. Luijten 6 , Gert Jan de Borst 3 , and Jeroen Hendrikse 6

1 Radiology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 2 University Medical Center Utrecht, Utrecht, Netherlands, 3 Vascular Surgery, University Medical Center Utrecht, Utrecht, Netherlands, 4 Bioengineering, Imperial College London, London, United Kingdom, 5 Pathology, University Medical Center Utrecht, Utrecht, Netherlands, 6 Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 7 Experimental Cardiology, University Medical Center Utrecht, Utrecht, Netherlands

First, the use ultra-high field 7T MR imaging to visualize the total burden of cerebral infarcts (both macro- and microinfarcts) was evaluated. Second, the presence of micro- and macroinfarcts was correlated with histopathology of carotid artery plaque. This study shows that a histopathological thinner fibrous cap is associated with more infarcts (both micro and macroinfarcts) in the hemisphere ipsilateral to a >70% symptomatic carotid artery stenosis. Other histopathological plaque characteristics were not related to infarcts (micro and macro). Microinfarcts are common in this patient group with symptomatic carotid artery stenosis but are most often find in combination with macroinfarcts.

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