Abstract #0520
Cerebral microinfarcts determined at 7T MRI are associated with a thin fibrous cap in ipsilateral carotid atherosclerotic plaque
Alexandra A.J. de Rotte 1 , Wouter Koning 2 , Anne G. den Hartog 3 , Sandra M. Bovens 4 , Aryan Vink 5 , Shahrzad Sepehrkhouy 5 , Jaco J.M. Zwanenburg 6 , Dennis W.J. Klomp 6 , Gerard Pasterkamp 7 , Frans L. Moll 3 , Peter L. Luijten 6 , Gert Jan de Borst 3 , and Jeroen Hendrikse 6
1
Radiology, University Medical Center
Utrecht, Utrecht, Utrecht, Netherlands,
2
University
Medical Center Utrecht, Utrecht, Netherlands,
3
Vascular
Surgery, University Medical Center Utrecht, Utrecht,
Netherlands,
4
Bioengineering,
Imperial College London, London, United Kingdom,
5
Pathology,
University Medical Center Utrecht, Utrecht, Netherlands,
6
Radiology,
University Medical Center Utrecht, Utrecht, Netherlands,
7
Experimental
Cardiology, University Medical Center Utrecht, Utrecht,
Netherlands
First, the use ultra-high field 7T MR imaging to
visualize the total burden of cerebral infarcts (both
macro- and microinfarcts) was evaluated. Second, the
presence of micro- and macroinfarcts was correlated with
histopathology of carotid artery plaque. This study
shows that a histopathological thinner fibrous cap is
associated with more infarcts (both micro and
macroinfarcts) in the hemisphere ipsilateral to a >70%
symptomatic carotid artery stenosis. Other
histopathological plaque characteristics were not
related to infarcts (micro and macro). Microinfarcts are
common in this patient group with symptomatic carotid
artery stenosis but are most often find in combination
with macroinfarcts.
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