Abstract #0521
Pronounced Visibility of Cerebral Venous Vasculature in Small Vessel Disease; A Susceptibility-weighted Imaging Study
Farhang F Jalilian 1,2 , David E Crane 1 , FuQiang Gao 1 , Sandra E Black 1,3 , and Bradley J MacIntosh 1,2
1
Heart and Stroke Foundation Canadian
Partnership for Stroke Recovery, Sunnybrook Research
Institute, Toronto, ON, Canada,
2
Medical
Biophysics, University of Toronto, Toronto, ON, Canada,
3
Division
of Neurology, Faculty of Medicine, University of
Toronto, Toronto, ON, Canada
Cerebral Small Vessel Disease (SVD) is the most
prevalent disease that affects the brain. We investigate
the use of susceptibility-weighted imaging (SWI) in
visualizing medullary veins and assessing the SVD. The
study involves automatic segmentation of: 1) venous
vasculature and 2) white matter lesions. Our results
show there is a higher vein fraction in white matter
lesions compared to normal white matter, and a positive
correlation between periventricular vein fraction and
SVD lesion burden. Our findings showcase the utility of
SWI and highlight the importance of investigating the
venous vasculature for its involvement in the etiology
of the SVD.
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