Abstract #0522
Simplified model for Gd-EOB-DTPA DCE-MRI liver function analysis
Mikael F. Forsgren 1,2 , Jose L. Ulloa 3 , and Paul D. Hockings 4,5
1
Wolfram MathCore AB, Linkping, Sweden, and
Center for Medical Image Science and Visualization(CMIV),
Linkping University, Linkping, Sweden,
2
Dept.
of Medical and Health Sciences, Linkping University,
Dept. of Radiation Physics, UHL County Council of
stergtland, Linkping, Sweden,
3
Bioxydyn
Ltd., Manchester, United Kingdom,
4
Drug
Safety and Metabolism, AstraZeneca AB, Mlndal, Sweden,
5
MedTech
West, Chalmers University of Technology, Gothenburg,
Sweden
Dynamic contrast-enhanced MRI seems promising for
non-invasive quantification of liver function. Recently
a model based method for the quantification was
published, and herein we tested if the number of
parameters could be reduced by linearizing the efflux
into the bile (MRP2), and still maintain sufficient
separation between normal and reduced liver function.
This model reduction was tested on rats treated with a
chemokine receptor antagonist that reduces liver
function. We found that the uptake of contrast was
unaffected by the model reduction of the efflux, and
that the reduced model was significantly able to
separate between normal and reduced function.
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