Phase-based contrast agent quantification using statistical modelling
Patrik Brynolfsson 1 and Anders Garpebring 1,2
Radiation Sciences, Ume University, Ume,
Gorter Center for high field MRI, Leiden University
Medical Center, Leiden, Zuid-Holland, Netherlands
A novel method for contrast agent (CA) quantification is
proposed. Phase changes linearly with CA concentration,
but is hard to use due to the ill-posed inversion from
phase-change to CA concentration. We regularize the
inversion with magnitude data in a statistical approach
and evaluate the result on simulated DCE-MRI exams. For
tissues with high CA concentration the novel method
performed better than using magnitude information only,
for low CA concentrations the methods were equivalent.
The next step is to test the method on in-vivo data
where many challenges still remain, such as phase-drift.
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