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Abstract #0528

Phase-based contrast agent quantification using statistical modelling

Patrik Brynolfsson 1 and Anders Garpebring 1,2

1 Radiation Sciences, Ume University, Ume, Sweden, 2 CJ Gorter Center for high field MRI, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands

A novel method for contrast agent (CA) quantification is proposed. Phase changes linearly with CA concentration, but is hard to use due to the ill-posed inversion from phase-change to CA concentration. We regularize the inversion with magnitude data in a statistical approach and evaluate the result on simulated DCE-MRI exams. For tissues with high CA concentration the novel method performed better than using magnitude information only, for low CA concentrations the methods were equivalent. The next step is to test the method on in-vivo data where many challenges still remain, such as phase-drift.

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