The Potential Advantage of High Resolution In Vivo 31P-MRS in the Assessment of Nonalcoholic Fatty Liver Disease

The advantage of high resolution in-vivo 31P-MRS in assessing nonalcoholic fatty liver disease (NAFLD) was investigated at 9.4T in CCl4-treated rats. In all spectra phosphomonoester (PME) and phosphodiester (PDE) were well resolved into phosphoethanolamine (PE) and phosphocholine (PC), and into glycerophosphorylethanolamine (GPE) and glycerophosphorylcholine (GPC), respectively. Those MRS measures quantifiable only in highly resolved spectra had higher correlations with histology than those conventional MRS measures. In multivariate analyses the statistical model allowed the classification and prediction of the animals according to disease severity with 70-80% accuracy. High resolution in-vivo 31P-MRS may further extend the applicability of 31P-MRS in assessing NAFLD.

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