Abstract #0533
Glutamine is the main source of 2-HG production in IDH1 mutant glioma cells
Jose Luis Izquierdo Garcia 1 , Pia Eriksson 1 , Cai Larry 1 , Myriam Chaumeil 1 , Russell O Pieper 2 , Joanna J Phillips 2 , and Sabrina M Ronen 1
1
Radiology, UCSF, San Francisco, CA, United
States,
2
Neurological
Surgery, Helen Diller Research Center, UCSF, San
Francisco, CA, United States
Mutations in Isocitrate dehydrogenase (IDH1) have been
reported in over 70% of low-grade gliomas and secondary
glioblastomas (GBM) and they are associated with the
accumulation of the oncometabolite 2-HG within the
tumor. Despite these observations, the metabolic fluxes
associated with 2-HG production are not fully
understood. This study demonstrates using 13C MRS in
combination 13C-labeled glucose and glutamine that
glucose does not contribute significantly to 2-HG
production and that glutamine is the main source of 2-HG
in our U87 GBM mutant IDH1 cells.
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