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Abstract #0540

Combined Imaging of Cl - and Na + at 7 Tesla: First Results in Brain Tumors

Armin M. Nagel 1 , Reiner Umathum 1 , Marc-Andr Weber 2,3 , Jan-Oliver Neumann 4 , and Armin Biller 5

1 Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2 Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Germany, 3 Radiology, German Cancer Research Center (DKFZ), Germany, 4 Dpt. of Neurosurgery, University Hospital of Heidelberg, Heidelberg, Germany, 5 Dpt. of Neuroradiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Chlorine (Cl - ) is the most abundant anion in the human body and is involved in many important physiological processes such as the regulation of the electric excitability and cell migration in cancer. Sodium (Na + ) plays also a fundamental role in cellular processes. In this work combined 35 Cl and 23 Na MRI was performed for the first time in brain tumor patients. In the calculation of the Cl - /Na + ratio maps differences in the point spread functions of 35 Cl and 35 Na MRI were accounted for. In the tissue affected by the gliomas, the measured Cl - /Na + ratio was markedly decreased compared to healthy brain tissue.

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