Combined Imaging of Cl - and Na + at 7 Tesla: First Results in Brain Tumors
Armin M. Nagel 1 , Reiner Umathum 1 , Marc-Andr Weber 2,3 , Jan-Oliver Neumann 4 , and Armin Biller 5
Medical Physics in Radiology, German Cancer
Research Center (DKFZ), Heidelberg, Germany,
and Interventional Radiology, University Hospital of
German Cancer Research Center (DKFZ), Germany,
of Neurosurgery, University Hospital of Heidelberg,
of Neuroradiology, German Cancer Research Center (DKFZ),
) is the most abundant anion in
the human body and is involved in many important
physiological processes such as the regulation of the
electric excitability and cell migration in cancer.
) plays also a fundamental role in
cellular processes. In this work combined
MRI was performed for the first time in brain tumor
patients. In the calculation of the Cl
maps differences in the point spread functions of
MRI were accounted for. In the tissue affected by the
gliomas, the measured Cl
was markedly decreased compared to healthy brain tissue.
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