Abstract #0541
Monitoring Tissue-Engineered Graft Oxygenation In Vivo by Fluorine-19 Magnetic Resonance Spectroscopy
Samuel A Stein 1 , Bradley P Weegman 1 , Thomas M Suszynski 2 , Meri T Firpo 3 , Melanie L Graham 2 , Klearchos K Papas 4 , and Michael Garwood 1
1
Radiology, University of Minnesota,
Minneapolis, MN, United States,
2
Surgery,
University of Minnesota, Minneapolis, MN, United States,
3
Medicine,
University of Minnesota, Minneapolis, MN, United States,
4
Surgery,
University of Arizona, Tucson, AZ, United States
Transplantation of tissue-engineered grafts (TEGs) has
the potential to treat numerous debilitating diseases.
Non-invasive monitoring of the oxygen partial pressure
(pO2) in TEGs is critically important because of the
harmful effects of prolonged or even short-term exposure
to hypoxia and anoxia. This pilot study evaluated the
utility of 19F-MRS in the non-invasive measurement of in
vivo pO2 within macroencapsulated TEGs following
implantation in the murine model. These preliminary
studies confirm that 19F-MRS can be used to
non-invasively measure pO2 in vivo within a TEG and
suggest that the encapsulated TEG becomes hypoxic 1 week
post-transplant despite the oxygen permeable membrane.
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