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Abstract #0541

Monitoring Tissue-Engineered Graft Oxygenation In Vivo by Fluorine-19 Magnetic Resonance Spectroscopy

Samuel A Stein 1 , Bradley P Weegman 1 , Thomas M Suszynski 2 , Meri T Firpo 3 , Melanie L Graham 2 , Klearchos K Papas 4 , and Michael Garwood 1

1 Radiology, University of Minnesota, Minneapolis, MN, United States, 2 Surgery, University of Minnesota, Minneapolis, MN, United States, 3 Medicine, University of Minnesota, Minneapolis, MN, United States, 4 Surgery, University of Arizona, Tucson, AZ, United States

Transplantation of tissue-engineered grafts (TEGs) has the potential to treat numerous debilitating diseases. Non-invasive monitoring of the oxygen partial pressure (pO2) in TEGs is critically important because of the harmful effects of prolonged or even short-term exposure to hypoxia and anoxia. This pilot study evaluated the utility of 19F-MRS in the non-invasive measurement of in vivo pO2 within macroencapsulated TEGs following implantation in the murine model. These preliminary studies confirm that 19F-MRS can be used to non-invasively measure pO2 in vivo within a TEG and suggest that the encapsulated TEG becomes hypoxic 1 week post-transplant despite the oxygen permeable membrane.

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