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Abstract #0562

Efficient measurement of liver T1, T2 and PDFF by multi-TR, multi-TE single breath-hold 1 H MR spectroscopy.

Gavin Hamilton 1 , Michael S Middleton 1 , Lisa Clark 1 , Tanya A Chavez 1 , Rohit Loomba 2 , and Claude B Sirlin 1

1 Department of Radiology, UC San Diego, San Diego, California, United States, 2 Department of Medicine, UC San Diego, San Diego, California, United States

We developed a rapid multi-TR, multi-TE 1 H MRS sequence for in vivo hepatic fat quantification and characterization that acquires 32 single-average spectra in a single breath-hold. Spectra were acquired without contrast at 3 Tesla in 252 adult subjects. T1 and T2 of liver fat and water, and liver liver proton density fat fraction (PDFF) were measured. Water and fat T1 values were strongly correlated, whereas water and fat T2 values were uncorrelated. For water, T2 increased with increasing T1, whereas for fat, T2 decreased with T1. For increasing PDFF, water T2 decreased and fat T2 increased.

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