Efficient measurement of liver T1, T2 and PDFF by multi-TR, multi-TE single breath-hold 1 H MR spectroscopy.
Gavin Hamilton 1 , Michael S Middleton 1 , Lisa Clark 1 , Tanya A Chavez 1 , Rohit Loomba 2 , and Claude B Sirlin 1
Department of Radiology, UC San Diego, San
Diego, California, United States,
of Medicine, UC San Diego, San Diego, California, United
We developed a rapid multi-TR, multi-TE
MRS sequence for
fat quantification and characterization that acquires 32
single-average spectra in a single breath-hold. Spectra
were acquired without contrast at 3 Tesla in 252 adult
subjects. T1 and T2 of liver fat and water, and liver
liver proton density fat fraction (PDFF) were measured.
Water and fat T1 values were strongly correlated,
whereas water and fat T2 values were uncorrelated. For
water, T2 increased with increasing T1, whereas for fat,
T2 decreased with T1. For increasing PDFF, water T2
decreased and fat T2 increased.
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