Clinical Effectiveness of Three Noninvasive Methods for Detecting Hepatic Fibrosis

Since liver biopsy -the reference method- has some significant limitations for detecting hepatic fibrosis, noninvasive technologies have been developed, such as MR Elastography (MRE), Fibroscan and FIBROSpect II. The purpose of this study was to evaluate the clinical effectiveness of these three methods in a single patient population with a consideration for interobserver variations of liver pathology. ROC analysis shows a diagnostic accuracy (>= F2) of 90.7%, 88.9% and 83.0% for MRE, FIBROSpect II and Fibroscan, respectively. MRE has the highest negative predictive value (90.0%), indicating patients without clinically significant fibrosis could be diagnosed by MRE and avoid liver biopsy.

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