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Abstract #0569

The subthalamic microlesion in Parkinson's disease: Investigating electrode insertion-related connectivity differences using resting-state fMRI

tefan Holiga 1 , Karsten Mueller 1 , Filip Ruzicka 2 , Duan Urgok 3 , Harald E. Mller 1 , Evzen Ruzicka 2 , Matthias L. Schroeter 1,4 , and Robert Jech 2

1 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2 Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague, Czech Republic, 3 Department of Radiation and Stereotactic Neurosurgery, Na Homolce Hospital, Prague, Czech Republic, 4 Clinic for Cognitive Neurology, University of Leipzig, Germany

Microlesion-effect (MLE) is a phenomenon appearing during implantation of deep-brain stimulation electrodes in subthalamic nucleus (STN) of patients suffering from Parkinsons disease (PD). It is associated with transient, but marked improved of patients motor symptoms. We took advantage of this invasive intervention and combined it with hypothesis-free resting-state fMRI analytical method of eigenvector centrality, which gave us a unique opportunity to study the impact of disrupted STN on the motor-circuitry in human PD in-vivo. We linked several central brain structures with the MLE. Further, brainstem, cerebellum and putamen/globus-pallidus were found to account for improvements in particular PD symptoms.

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