Differentiation of Early-Stage Parkinsonisms using Diffusion Kurtosis/Tensor Imaging
Kenji Ito 1 , Makoto Sasaki 1 , Chigumi Ohtuka 2 , Ikuko Uwano 1 , Fumio Yamashita 1 , Satomi Higuchi 1 , Jonathan Goodwin 1,3 , Taisuke Harada 1,3 , and Yasuo Terayama 2
Division of Ultrahigh Field MRI, Institute
for Biomedical Sciences, Iwate Medical University,
of Neurology and Gerontology, Iwate Medical University,
of Diagnostic and Interventional Radiology, Hokkaido
University Hospital, Sapporo, Hokkaido, Japan
The differential diagnosis of early-stage parkinsonisms
such as PD, MSA-P, MSA-C, and PSP is often difficult.
Hence, we investigated whether diffusion kurtosis
imaging (DKI), which enables detecting subtle
pathological changes, can differentiate these disorders
by using an automated ROI-based quantitative analysis.
Mean kurtosis (MK) values of the gray matter structures
were significantly different between patients with PD
and PSP, while fractional anisotropy and/or mean
diffusivity in the white matter structures were
different between patients with PD and patients with MSA-C/PSP.
A combined usage of DKI and other classical diffusion
metrics can therefore contribute to the differential
diagnosis of early-stage parkinsonisms.
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