Abstract #0571
MRS and diffusion MRI of the spinal cord in Friedreichs Ataxia
Pierre-Gilles Henry 1 , Dinesh Deelchand 1 , Isabelle Iltis 1 , Diane Hutter 1 , Khalaf O Bushara 1 , Gulin Oz 1 , and Christophe Lenglet 1
1
Center for Magnetic Resonance Research,
University of Minnesota, Minneapolis, MN, United States
We measured
1
H
MR spectra and acquired diffusion MRI data of the spinal
cord in patients with Friedreichs Ataxia and control
subjects at 3T. With
1
H
MRS, we observed a 40% decrease in NAA and 46% increase
in myo-inositol concentrations in the spinal cord of
patients compared to controls, reflecting neuronal
degeneration and gliosis, respectively. With diffusion,
we observed a decrease in fractional anisotropy of the
spinal cord, as well as alteration of the nerve roots.
These findings may be useful to monitor disease
progression and assess therapeutic efficacy in
prospective clinical trials.
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