Sub-Millimeter Imaging of Brain-Free Water for Rapid Volume Assessment in Atrophic Brains
Govind Nair 1 , Katherine C Gao 1 , Irene C. M. Cortese 1 , Alan Koretsky 1 , and Daniel S Reich 1
NINDS, National Institutes of Health,
Bethesda, MD, United States
Cerebral atrophy is a common feature in neurological
diseases that contributes to disability. CSF volume
increases to occupy the space left by the atrophying
brain. CSF volume can be quantified by intensity
thresholding a heavily T2-weighted scan. This brain-free
water (BFW) volume, and BFW-volume normalized to the
intracranial space, exhibited significant correlation
with various clinical measures of disability in 83
multiple sclerosis cases. These measures outperformed
brain volume measurements using Lesion-TOADS by 8-19%.
The better performance of this new algorithm was
attributed to higher resolution enabling improved
visualization of sulcal spaces, and the simpler
segmentation algorithm in this new BFW-method.
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