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Abstract #0573

A Multimodal Approach for Comprehensive Segmentation of the Substantia Nigra

Jason Langley 1 , Daniel Huddleston 2,3 , Xiangchuan Chen 1 , Jan Sedlacik 4 , Shiyang Chen 1 , and Xiaoping Hu 1

1 Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States, 2 Department of Neurology, Emory University, Atlanta, GA, United States, 3 Center for Health Research, Southeast, Kaiser Permanente, Atlanta, GA, United States, 4 Department of Neuroradiology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany

Degeneration of the substantia niagra(SN) is a hallmark of many neurodegenerative disorders including Parkinsons disease and Alzheimers disease. Visualization and volumetric quantification of the SN would be beneficial to early detection of both diseases. Magnetization transfer contrast (MTC) imaging is sensitive to neuromelanin-containing structures in the brain and susceptibility weighted imaging (SWI) is sensitive to iron. This abstract compares the segmentation results of the SN from MTC and SWI images. Both methods give volumetric estimates that are approximately similar but the spatial overlap between the two regimes is ~11%. Indicating a multimodal approach will yield more accurate segmentation results.

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